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recombinant human igfbp6  (R&D Systems)


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    R&D Systems recombinant human igfbp6
    Recombinant Human Igfbp6, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/igfbp+6+proteins/Recombinant+Human+IGFBP-6+Protein%2C+CF/bio_rxiv__2025__06__12__657772-340-4-8
    Average 93 stars, based on 7 article reviews
    recombinant human igfbp6 - by Bioz Stars, 2026-09
    93/100 stars

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    Recombinant:

    Article Title: Endoglin regulates cancer-stromal cell interactions in prostate tumors
    Article Snippet: .. Human recombinant IGF-1, IGFBP-4 and IGFBP-6 proteins, and the neutralizing anti-IGFBP-4 were obtained from R&D Systems. .. The tumors were ground and homogenized in lysis buffer (150 mM NaCl, 300 mM sucrose, 1% Triton X-100, 0.5% sodium deoxycholate, 50 mM Tris-HCl pH 7.5) containing a cocktail of protease (Roche), and phosphatase (Calbiochem-EMD, Darmstadt, Germany) inhibitors.

    Article Title: Endoglin Regulates Cancer–Stromal Cell Interactions in Prostate Tumors
    Article Snippet: All cell lines were verified by morphology, mouse and human endoglin-specific PCR, certified mycoplasma-negative by PCR (Lonza), and primary cell cultures used within the indicated passage numbers. .. Human recombinant IGF-I, IGFBP-4, and IGFBP-6 proteins, and the neutralizing anti-IGFBP-4 were obtained from R&D Systems. ..



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    IGFBP-6 shows higher expression in F508del-CFTR CFBE cells and is further increased after LPS treatment. (A) Total RNA was extracted and qRT-PCR was performed in order to quantify IGFBP-6 mRNA normalized to GADPH as housekeeping gene. Data represent the mean ± SEM ( n = 3). Statistical significance tested using paired two-tailed t -test. (B) Immunoblots of basal expression of IGFBP-6 in Wt and F508del-CFTR CFBE cells. (C) Data represent the mean ± SEM of the ratio IGFBP-6/Calnexin ( n = 3). Statistical significance tested using paired two-tailed t -test. (D,E) Cells were treated with 1 μg/ml LPS for 4 h. Total RNA was extracted and qRT-PCR was performed in order to quantify IGFBP-6 mRNA s normalized first to GADPH as housekeeping gene and then to control untreated cells. Data represent the mean ± SEM ( n = 4). Statistical significance tested using two-way ANOVA with Tukey’s multiple comparisons test (F) Immunoblots of IGFBP-6 following treatment with 1 μg/ml LPS for 24 h. (G) Data represent the mean ± SEM of the ratio IGFBP-6/Calnexin normalized to Calnexin control ( n = 3–4). * p < 0.05; ** p < 0.01; **** p < 0.0001.

    Journal: Frontiers in Molecular Biosciences

    Article Title: Insulin-Like Growth Factor Binding Protein (IGFBP-6) as a Novel Regulator of Inflammatory Response in Cystic Fibrosis Airway Cells

    doi: 10.3389/fmolb.2022.905468

    Figure Lengend Snippet: IGFBP-6 shows higher expression in F508del-CFTR CFBE cells and is further increased after LPS treatment. (A) Total RNA was extracted and qRT-PCR was performed in order to quantify IGFBP-6 mRNA normalized to GADPH as housekeeping gene. Data represent the mean ± SEM ( n = 3). Statistical significance tested using paired two-tailed t -test. (B) Immunoblots of basal expression of IGFBP-6 in Wt and F508del-CFTR CFBE cells. (C) Data represent the mean ± SEM of the ratio IGFBP-6/Calnexin ( n = 3). Statistical significance tested using paired two-tailed t -test. (D,E) Cells were treated with 1 μg/ml LPS for 4 h. Total RNA was extracted and qRT-PCR was performed in order to quantify IGFBP-6 mRNA s normalized first to GADPH as housekeeping gene and then to control untreated cells. Data represent the mean ± SEM ( n = 4). Statistical significance tested using two-way ANOVA with Tukey’s multiple comparisons test (F) Immunoblots of IGFBP-6 following treatment with 1 μg/ml LPS for 24 h. (G) Data represent the mean ± SEM of the ratio IGFBP-6/Calnexin normalized to Calnexin control ( n = 3–4). * p < 0.05; ** p < 0.01; **** p < 0.0001.

    Article Snippet: Cells were treated for 24 h with 0.1% DMSO or 200 ng/ml IGFBP-6 (PeproTech) or 3 µM VX-661 + 3 µM VX-445 (Selleck Chemicals) +/− 200 ng/ml IGFBP-6.

    Techniques: Expressing, Quantitative RT-PCR, Two Tailed Test, Western Blot

    IGFBP-6 is reduced by Dimethyl fumarate. (A) Cells were treated with 0.1% DMSO, 1 μg/ml LPS ± 50 µM DMF or (B) PBS, 30 ng/ml IL-1β + 30 ng/ml TNFα ± 50 µM DMF for 4 h. Total RNA was extracted and qRT-PCR was performed in order to quantify IGFBP mRNA normalized to GADPH as housekeeping gene and then to control untreated cells. Data represent the mean ± SEM ( n = 4). (C) IGFBP-6 secretion after stimulation with 0.1% DMSO, 1 μg/ml LPS, 30 ng/ml IL-1β + 30 ng/ml TNFα ± 50 µM DMF for 24 h. Data represent the mean ± SEM ( n = 3). * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001. Statistical significance tested using two-way ANOVA with Tukey’s multiple comparisons test to the control (Wt or F508del) for each cell line.

    Journal: Frontiers in Molecular Biosciences

    Article Title: Insulin-Like Growth Factor Binding Protein (IGFBP-6) as a Novel Regulator of Inflammatory Response in Cystic Fibrosis Airway Cells

    doi: 10.3389/fmolb.2022.905468

    Figure Lengend Snippet: IGFBP-6 is reduced by Dimethyl fumarate. (A) Cells were treated with 0.1% DMSO, 1 μg/ml LPS ± 50 µM DMF or (B) PBS, 30 ng/ml IL-1β + 30 ng/ml TNFα ± 50 µM DMF for 4 h. Total RNA was extracted and qRT-PCR was performed in order to quantify IGFBP mRNA normalized to GADPH as housekeeping gene and then to control untreated cells. Data represent the mean ± SEM ( n = 4). (C) IGFBP-6 secretion after stimulation with 0.1% DMSO, 1 μg/ml LPS, 30 ng/ml IL-1β + 30 ng/ml TNFα ± 50 µM DMF for 24 h. Data represent the mean ± SEM ( n = 3). * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001. Statistical significance tested using two-way ANOVA with Tukey’s multiple comparisons test to the control (Wt or F508del) for each cell line.

    Article Snippet: Cells were treated for 24 h with 0.1% DMSO or 200 ng/ml IGFBP-6 (PeproTech) or 3 µM VX-661 + 3 µM VX-445 (Selleck Chemicals) +/− 200 ng/ml IGFBP-6.

    Techniques: Quantitative RT-PCR

    Anti-IGFBP-6 antibodies increased pro-inflammatory cytokines expression. (A) F508del-CFTR CFBE cells were treated with PBS or 0.2–200 ng/ml IGFBP-6 for 4 h. Statistical significance tested using two-way ANOVA with Tukey’s multiple comparisons test. (B) Cells were treated with 1 μg/ml LPS ± an antibody directed against IGFBP-6 (1 μg/ml) for 4 h. Total RNA was extracted and qRT-PCR was performed in order to quantify IL-1β, IL-6 and TNF-α mRNAs normalized to GADPH as housekeeping gene and then to control untreated cells. Data represent the mean ± SEM ( n = 3). Statistical significance tested using paired two-tailed t -test.

    Journal: Frontiers in Molecular Biosciences

    Article Title: Insulin-Like Growth Factor Binding Protein (IGFBP-6) as a Novel Regulator of Inflammatory Response in Cystic Fibrosis Airway Cells

    doi: 10.3389/fmolb.2022.905468

    Figure Lengend Snippet: Anti-IGFBP-6 antibodies increased pro-inflammatory cytokines expression. (A) F508del-CFTR CFBE cells were treated with PBS or 0.2–200 ng/ml IGFBP-6 for 4 h. Statistical significance tested using two-way ANOVA with Tukey’s multiple comparisons test. (B) Cells were treated with 1 μg/ml LPS ± an antibody directed against IGFBP-6 (1 μg/ml) for 4 h. Total RNA was extracted and qRT-PCR was performed in order to quantify IL-1β, IL-6 and TNF-α mRNAs normalized to GADPH as housekeeping gene and then to control untreated cells. Data represent the mean ± SEM ( n = 3). Statistical significance tested using paired two-tailed t -test.

    Article Snippet: Cells were treated for 24 h with 0.1% DMSO or 200 ng/ml IGFBP-6 (PeproTech) or 3 µM VX-661 + 3 µM VX-445 (Selleck Chemicals) +/− 200 ng/ml IGFBP-6.

    Techniques: Expressing, Quantitative RT-PCR, Two Tailed Test

    IGFBP-6 shows higher expression in F508del / F508del nasal epithelial cells from three CF donors and reduces pro-inflammatory cytokines expression. (A) Total RNA was extracted from 2 patients homozygous for F508del mutation and 2 non-CF donors. qRT-PCR was performed in order to quantify IGFBP-6 mRNA normalized to GADPH as housekeeping gene. Data represent the mean ± SEM ( n = 4). Statistical significance tested using paired two-tailed t -test (B) Cells were treated with 0.1% DMSO, 1 μg/ml LPS, 30 ng/ml IL-1β + 30 ng/ml TNFα ± 50 µM DMF for 4 h. Total RNA was extracted and qRT-PCR was performed in order to quantify IGFBP mRNA normalized to control untreated cells. Data represent the mean ± SEM ( n = 4). (C) Cells were treated with 200 ng/ml IGFBP-6 for 4 h. Total RNA was extracted and qRT-PCR was performed in order to quantify IL-1β, IL-6 and TNFα mRNAs normalized to control untreated cells. Data represent the mean ± SEM ( n = 4). * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001. Statistical significance tested using two-way ANOVA with Tukey’s multiple comparisons test to the control for (Wt or F508del) each cell line.

    Journal: Frontiers in Molecular Biosciences

    Article Title: Insulin-Like Growth Factor Binding Protein (IGFBP-6) as a Novel Regulator of Inflammatory Response in Cystic Fibrosis Airway Cells

    doi: 10.3389/fmolb.2022.905468

    Figure Lengend Snippet: IGFBP-6 shows higher expression in F508del / F508del nasal epithelial cells from three CF donors and reduces pro-inflammatory cytokines expression. (A) Total RNA was extracted from 2 patients homozygous for F508del mutation and 2 non-CF donors. qRT-PCR was performed in order to quantify IGFBP-6 mRNA normalized to GADPH as housekeeping gene. Data represent the mean ± SEM ( n = 4). Statistical significance tested using paired two-tailed t -test (B) Cells were treated with 0.1% DMSO, 1 μg/ml LPS, 30 ng/ml IL-1β + 30 ng/ml TNFα ± 50 µM DMF for 4 h. Total RNA was extracted and qRT-PCR was performed in order to quantify IGFBP mRNA normalized to control untreated cells. Data represent the mean ± SEM ( n = 4). (C) Cells were treated with 200 ng/ml IGFBP-6 for 4 h. Total RNA was extracted and qRT-PCR was performed in order to quantify IL-1β, IL-6 and TNFα mRNAs normalized to control untreated cells. Data represent the mean ± SEM ( n = 4). * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001. Statistical significance tested using two-way ANOVA with Tukey’s multiple comparisons test to the control for (Wt or F508del) each cell line.

    Article Snippet: Cells were treated for 24 h with 0.1% DMSO or 200 ng/ml IGFBP-6 (PeproTech) or 3 µM VX-661 + 3 µM VX-445 (Selleck Chemicals) +/− 200 ng/ml IGFBP-6.

    Techniques: Expressing, Mutagenesis, Quantitative RT-PCR, Two Tailed Test